Like superheroes in our body, Leukocytes (also known as white blood cells (WBC)) work tirelessly to keep us safe from harmful invaders like infections and diseases. When leukocytes are found in urine, it indicates infection or inflammation within the urinary system. Let us have a detailed discussion on pyuria (leukocytes in urine) and how it impacts our health.
What are Leukocytes?
Leukocytes are a type of blood cells. They are synthesised in the bone marrow and lymphatic system. They defend the body against infections, illnesses, and foreign invaders. Pathologists have classified leukocytes into several different types, each with its specific function:
- Neutrophils: These most common types of leukocytes are the first responders to fight off bacterial and fungal infections.
- Lymphocytes: These cells are responsible for the body’s immune response, including the production of antibodies. The types of lymphocytes are T lymphocytes (natural killer cells) and B lymphocytes (which produce antibodies to fight infection).
- Monocytes: These larger leukocytes play a role in the body’s inflammatory response and can develop into macrophages or dendritic cells.
- Eosinophils: These cells are responsible for the body’s response to parasitic infections and allergic reactions.
- Basophils: These cells release histamine and other chemicals during an allergic response.
Leukocytes are typically found in the bloodstream but can also be present in other bodily fluids, including urine.
Causes of Leukocytes in Urine
The presence of leukocytes in urine, or pyuria, can be caused by various factors. Some of the most common causes include:
- Urinary Tract Infection (UTI): The most common cause of leukocytes in urine is a UTI. Bacteria, viruses, or fungi can cause UTIs. The condition can affect any part of the urinary tract (the bladder, urethra, or kidneys).
- Kidney Infections (pyelonephritis): This type of UTI explicitly affects the kidneys. It can lead to the presence of leukocytes in the urine.
- Sexually Transmitted Infections (STIs): Certain STIs, such as chlamydia or gonorrhoea, can cause inflammation in the urinary tract and lead to the presence of leukocytes in the urine.
- Interstitial Cystitis: This chronic condition causes bladder pressure, pain, and discomfort and can result in leukocytes in the urine.
- Kidney Stones: Kidney stones can lead to inflammation and leukocytes in the urine.
- Certain Medications: Some medications, such as antibiotics or chemotherapy drugs, can cause the presence of leukocytes in the urine as a side effect.
- Systemic Conditions: Certain medical diseases, such as genitourinary cancer (prostate, bladder, or kidney cancer), blood diseases (sickle cell disease), or holding urine for a long time can result in leukocytes in the urine.
It’s essential to remember that leukocytes in the urine do not always indicate a serious health issue. Sometimes, it may be a normal response to physical activity or other non-pathological factors.